?The development of a novel ultrashort antimicrobial peptide nanoparticles with potent antimicrobial effect

Conventional antibiotics are facing significant microbial resistance, which has recently reached previously unnoticed critical levels. As a result of this situation, large proportion antimicrobial agents currently used in the clinic have significantly reduced therapeutic potential. Antimicrobial peptides (AMPs) may offer medical community an alternative strategy to traditional fight against resistance. Current research efforts focused on developing technologies that reduce AMP toxicity while retaining their potent activity and possibly improving delivery. The ionotropic gelation method was encapsulate novel in-house designed ultrashort peptide (USAMP) into chitosan-based nanoparticles (CS-NPs) study. WRWRWR -CS-NPs were tested for antibacterial kinetics two strains Staphylococcus aureus four days, developed showed 3-log decrease number colonies when compared CS-NP 5-log control bacteria. Loaded CS-NPs could represent innovative approach develop delivery systems based NPs technology achieving effects multi-drug resistant biofilm forming bacteria with negligible systemic synthetic costs obstructing clinical development AMPs generally.